Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia
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چکیده
منابع مشابه
P-198: Analysis of Expression Level of TEX12 Gene in Testis Tissues of Severe Oligozoospermic and Non-Obstructive Azoospermic Men
Background: During the first meiotic prophase, alignment and synapsis of the homologous chromosomes are mediated by the synaptonemal complex. Incorrect assembly of the synaptonemal complex leads to impaired recombination and cell death, which in humans, causes infertility in males. Testis-expressed gene 12 (TEX12) is a germ cell-specific gene that is located on the chromosome 11 (11q22) in huma...
متن کاملP-230: Analysis of TEX15 Expression in Testis Tissues of Severe Oligozoospermic and Non-Obstructive Azoospermic Men Referred to Royan Institute
Background: TEX15 is a novel protein that is required for chromosomal synapsis and meiotic recombination. Human TEX15 is located on chromosome 8(8p12 region) and expressed in testis and ovary, as is its mouse ortholog. Loss of TEX15 function in mice causes early meiotic arrest in males but not in females. Specifically, TEX15 deficient spermatocytes exhibit a failure in chromosomal synapsis. In ...
متن کاملP-195: Analysis of Expression Level of Tex11 Gene in Obstructive and Non-Obstructive Azoospermic Men Referred to Royan Institute
Background: About 15% of couples worldwide suffer from infertility problem that half of these cases are related to male infertility. Spermatogenesis is a cumulative process and thousands of genes are involved in it. Change in one of these genes or their products can cause male infertility. Tex11 is a germ cell specific gene that is located on the X chromosome (Xq13.1 region). This gene was iden...
متن کاملScreening of two closed mutations in CFTR gene of Iranian infertile men with non-obstructive azoospermia
Background The genetic association between cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and male infertility due to congenital bilateral absence of vas deferens (CBAVD) is well established. Mutant CFTR, however may also be involved in the etiology of male infertility in non-CBAVD cases. The present study was conducted to estimate the frequency of ΔI507 and ΔF508 CFT...
متن کاملFrequency of CYP1A1 Gene Polymorphisms in Infertile Men with Non-obstructive Azoospermia
Background and Aims: The cytochrome P450 1A1 (CYP1A1) plays a curial role in phase I metabolism of polycyclic aromatic hydrocarbons to their ultimate biologically active intermediates that have potential reproductive toxicity in men. Reproductive functions in men may be impaired by many environmental, physiologic, and genetic factors. The majority of the environmental factors are xenobiotics. M...
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ژورنال
عنوان ژورنال: JBRA Assisted Reproduction
سال: 2018
ISSN: 1518-0557
DOI: 10.5935/1518-0557.20180030